Dear Nadzreen,
The backbone for wireless communication system can be designed using OptiSystem, where the data is carried over fiber. There are many examples on this topic, one of them is (64QAM-OFDM Signal ROF transmission). Also, please note that OptiSystem have over than 580 components that can be used for supporting 5G and IOT applications.
Let me know if you a specific requirement over my email ahmad.atieh@optiwave.com and we can discuss further.
Regards,
Ahmad