Hi zakarya
As aasif has very well explained the different amplifier that u can employ and fayiqa has put a simulating perspective of the same. In regards to ur next query i would say that certainly there is a difference between the above formats and it would depend on the system design overall that would show some differences in the eye diagram. You better implement them in the same system design to see the difference. I hope you got me.
Regards
Burhan